The topic of the relation between science and religion holds an important status in the field of the philosophy of religion. It defines the theological framework and thought in human life. Some contemporary theories have brought about certain doubts regarding the value of religion and how it can be relied on in revealing reality. A real question has been put forward regarding the nature of the relation between science and religion, whether it is agreeable or in conflict. Based on this, different groups have explained the nature of this relation and the epistemic foundation that governs it. It has a clear effect on the method of life, in culture, politics and society. The Islamic world was not far from these attractions, and gave a strong influence. The correct Islamic theory that does not see opposition with scientific findings and is in conformity. The paper follows a descriptive analytical method in explain the pillars of the relation between science and religion, and the theories in the West and the Islamic world, and explains the epistemic method in Islamic thought, that has stayed preserved in its position, being the basis that guides humankind and reality of humanity.